2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2418):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-178543
    (2'OMe-5'p-m6A)pG
    (2'OMe-5'p-m6A)pG is a monomeric raw material that can be used for nucleic acid synthesis.
    (2'OMe-5'p-m6A)pG
  • HY-43058
    5'-O-DMT-ibu-rG
    5'-O-DMT-ibu-rG (5'-O-DMT-N2-isobutyrylguanosine) is a chemically modified guanosine derivative that can be used as a novel DNA-binding molecule for the development of effective and selective anti-cancer agents.
    5'-O-DMT-ibu-rG
  • HY-W570891
    DMTr-LNA-C(Bz)-3-CED-phosphoramidite
    		98.70%
    DMTr-LNA-C(Bz)-3-CED-phosphoramidite is a purine nucleoside analog that can be used to synthesize oligonucleotides.
    DMTr-LNA-C(Bz)-3-CED-phosphoramidite
  • HY-178528
    DMTr-2'-O-Me-rU-3'-(L)-DPSE-phosphoramidite
    DMTr-2'-O-Me-rU-3'-(L)-DPSE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-Me-rU-3'-(L)-DPSE-phosphoramidite
  • HY-178656
    DMTr-2'-O-C6-rG(iBu)-3'-CE-phosphoramidite
    DMTr-2'-O-C6-rG(iBu)-3'-CE-Phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-C6-rG(iBu)-3'-CE-phosphoramidite
  • HY-W746941
    2-Methylthio-cis-zeatin riboside
    2-Methylthio-cis-zeatin riboside (ms2io6A) , a hypermodified adenosine derivative, is present in the transfer RNA of Salmonella ryphimurium.
    2-Methylthio-cis-zeatin riboside
  • HY-W969826
    2'-O-Propargylcytidine
    2'-O-Propargylcytidine is a monomeric raw material that can be used for nucleic acid synthesis.
    2'-O-Propargylcytidine
  • HY-154242
    8-Methylguanosine
    8-Methylguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    8-Methylguanosine
  • HY-A0061R
    Trifluridine (Standard)
    Trifluridine (Standard) is the analytical standard of Trifluridine. This product is intended for research and analytical applications. Trifluridine (Trifluorothymidine) is an irreversible and orally active thymidylate synthase inhibitor, and thereby suppressing DNA synthesis. Trifluridine is an antiviral molecule used for research of HSV, rhabdovirus and orthopoxvirus infection. Trifluridine induces cell apoptosis and autophagy. Trifluridine is also an anticancer agent used in studies of metastatic colorectal cancer, gastrointestinal tumors.
    Trifluridine (Standard)
  • HY-154604
    1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine 3'-CE phosphoramidite
    1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine 3'-CE phosphoramidite is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
    1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine 3'-CE phosphoramidite
  • HY-154059
    2’-Deoxy-2’-fluorouridine 5’-monophosphate triethyl ammonium
    2’-Deoxy-2’-fluorouridine 5’-monophosphate triethyl ammonium is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Deoxy-2’-fluorouridine 5’-monophosphate triethyl ammonium
  • HY-W011683S7
    2'-Deoxyadenosine monohydrate-15N5
    2'-Deoxyadenosine monohydrate-15N5 is the 15N labeled 2'-Deoxyadenosine monohydrate (HY-W011683). 2′-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine monohydrate inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine monohydrate activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine monohydrate inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine monohydrate inhibits the growth of various cells. 2'-Deoxyadenosine monohydrate has an anticancer effect on colon cancer.
    2'-Deoxyadenosine monohydrate-<sup>15</sup>N<sub>5</sub>
  • HY-134248A
    Tubercidin 5'-triphosphate tetrasodium
    Tubercidin 5'-triphosphate (7-Deazaadenosine 5'-triphosphate) tetrasodium, a nucleoside analog, is an active metabolite of Tubercidin (HY-100126).
    Tubercidin 5'-triphosphate tetrasodium
  • HY-W393396
    3'-NH2-ddC
    3'-NH2-ddC is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-NH2-ddC
  • HY-177059
    Nitrobenzylthioinosine 5'-monophosphate
    Nitrobenzylthioinosine 5'-monophosphate (NBMPR-P), a nucleoside analog, is a prodrug of the potent nucleoside transport inhibitor Nitro-benzylthioinosine (NBMPR) (HY-W010936). Nitrobenzylthioinosine 5'-monophosphate blocks nucleoside transport in vivo and prevents host toxicity in tumor-bearing mice administered with highdoses of Tubercidin (HY-100126).
    Nitrobenzylthioinosine 5'-monophosphate
  • HY-131774A
    2-AHT-ATP sodium
    2-AHT-ATP (2-(6-Aminohexyl)thio-ATP) sodium is a derivative of ATP (HY-B2176). 2-AHT-ATP can be used in the synthesis of biotinylated ATP derivatives.
    2-AHT-ATP sodium
  • HY-178553
    5-Aminpropargyl UTP
    5-Aminpropargyl UTP is a monomeric raw material that can be used for nucleic acid synthesis.
    5-Aminpropargyl UTP
  • HY-131816
    5'-dUMPS
    5'-dUMPS is a competitive inhibitor or regulator of enzymes that interacts with 2′-deoxypyrimidine-5′-monophosphate.
    5'-dUMPS
  • HY-178600
    2'-O-4'-C-Locked-rC(Bz)
    2'-O-4'-C-Locked-rC(Bz) is a monomeric raw material that can be used for nucleic acid synthesis.
    2'-O-4'-C-Locked-rC(Bz)
  • HY-137669
    pApG
    pApG is a monomeric raw material that can be used for nucleic acid synthesis.
    pApG